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Potent Taccalonolides, AF and AJ, Inform Significant Structure Activity Relationships and Tubulin as the Binding Site of These Microtubule Stabilizers
The taccalonolides are a class of microtubule stabilizing agents isolated from plants of the genus Tacca. In efforts to define their structure activity relationships, we isolated 5 new taccalonolides, AC-AF, and H2, from one fraction of an ethanol extract of Tacca plantaginea. The structures were el...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234588/ https://ncbi.nlm.nih.gov/pubmed/22040100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209045k |
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