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Dissecting the Genetics of Complex Inheritance: Linkage Disequilibrium Mapping Provides Insight into Crohn Disease

Family studies for Crohn disease (CD) report extensive linkage on chromosome 16q and pinpoint NOD2 as a possible causative locus. However, linkage is also observed in families that do not bear the most frequent NOD2 causative mutations, but no other signals on 16q have been found so far in published...

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Detalhes bibliográficos
Main Authors: Elding, Heather, Lau, Winston, Swallow, Dallas M., Maniatis, Nikolas
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234369/
https://ncbi.nlm.nih.gov/pubmed/22152681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.11.006
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