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Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy

Osteoclasts (OCs) are responsible for bone resorption in inflammatory joint diseases. Monocyte chemotactic protein-1 (MCP-1) has been shown to induce differentiation of monocytes to OC precursors, but nothing is known about the underlying mechanisms. Here, we elucidate how MCPIP, induced by MCP-1, m...

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Detalhes bibliográficos
Main Authors: Wang, Kangkai, Niu, Jianli, Kim, Hyunbae, Kolattukudy, Pappachan E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234012/
https://ncbi.nlm.nih.gov/pubmed/21990425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjr021
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