Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins

Light chain amyloidosis (AL) involves overproduction of amyloidogenic light chain proteins (LC) leading to heart failure, yet the mechanisms underlying tissue toxicity remain unknown. We hypothesized that LC induces endothelial dysfunction in non-AL human microvasculature and apoptotic injury in hum...

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Hlavní autoři: Migrino, Raymond Q., Truran, Seth, Gutterman, David D., Franco, Daniel A., Bright, Megan, Schlundt, Brittany, Timmons, Mitchell, Motta, Angelica, Phillips, Shane A., Hari, Parameswaran
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2011
Témata:
Vascular Biology and Microcirculation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233808/
https://ncbi.nlm.nih.gov/pubmed/21963839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00503.2011
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