Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins

Light chain amyloidosis (AL) involves overproduction of amyloidogenic light chain proteins (LC) leading to heart failure, yet the mechanisms underlying tissue toxicity remain unknown. We hypothesized that LC induces endothelial dysfunction in non-AL human microvasculature and apoptotic injury in hum...

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Autors principals: Migrino, Raymond Q., Truran, Seth, Gutterman, David D., Franco, Daniel A., Bright, Megan, Schlundt, Brittany, Timmons, Mitchell, Motta, Angelica, Phillips, Shane A., Hari, Parameswaran
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
Matèries:
Vascular Biology and Microcirculation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233808/
https://ncbi.nlm.nih.gov/pubmed/21963839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00503.2011
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