Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase Iiib ALLOW study)

OBJECTIVES: To assess the effect of a temporary interruption in subcutaneous (SC) abatacept on immunogenicity, safety and efficacy in patients with active rheumatoid arthritis despite methotrexate in a phase III trial. METHODS: Following a 12-week open-label introduction (period I; intravenous abata...

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Autori principali: Kaine, Jeffrey, Gladstein, Geoffrey, Strusberg, Ingrid, Robles, Manuel, Louw, Ingrid, Gujrathi, Sheila, Pappu, Ramesh, Delaet, Ingrid, Pans, Miranda, Ludivico, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2011
Soggetti:
Clinical and Epidemiological Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233696/
https://ncbi.nlm.nih.gov/pubmed/21917824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200344
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