Polymeric Nanoparticle Encapsulated Hedgehog Pathway Inhibitor HPI-1 (“NanoHHI”) Inhibits Systemic Metastases in an Orthotopic Model of Human Hepatocellular Carcinoma

PURPOSE: To illustrate the prognostic significance of hedgehog (Hh) signaling in hepatocellular carcinoma (HCC) patients, and to evaluate the efficacy of a novel nanoparticle-encapsulated inhibitor of the Hh transcription factor, Gli-1 (“NanoHHI”) using in vitro and in vivo models of human HCC. EXPE...

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Main Authors: Xu, Yang, Chenna, Venugopal, Hu, Chaoxin, Sun, Hai-Xiang, Khan, Mehtab, Bai, Haibo, Yang, Xin-Rong, Zhu, Qin-Feng, Sun, Yun-Fan, Maitra, Anirban, Fan, Jia, Anders, Robert A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233659/
https://ncbi.nlm.nih.gov/pubmed/21868763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0950
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