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Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major.

We have determined the nucleotide sequence of the dihydrofolate reductase-thymidylate synthetase (DHFR-TS) gene of the protozoan parasite Leishmania major (dihydrofolate reductase, EC 1.5.1.3 and thymidylate synthase, EC 2.1.1.45). The DHFR-TS protein is encoded by a single 1560-base-pair open readi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Beverley, S M, Ellenberger, T E, Cordingley, J S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323343/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3458220/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.8.2584
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