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The pH sensitivity of −NH exchange in LnDOTA-tetraamide complexes varies with amide substituent

The amide proton exchange rates in various lanthanide(III) DOTA-tetraamide complexes were investigated by CEST as a function of variable chemical structures and charges on the amide substituents. Comparisons were made between YbDOTA-(gly)(4)(−) (Yb-1), YbDOTA-(NHCH(2)PO(3))(4)(5−) (Yb-2), and YbDOTA...

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Autores principales: Opina, Ana Christina L., Wu, Yunkou, Zhao, Piyu, Kiefer, Garry, Sherry, A. Dean
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233223/
https://ncbi.nlm.nih.gov/pubmed/22144023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmmi.445
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