Anti-MuSK autoantibodies block binding of collagen Q to MuSK

OBJECTIVE: Muscle-specific receptor tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) accounts for 5%–15% of autoimmune MG. MuSK mediates the agrin-signaling pathway and also anchors the collagenic tail subunit (ColQ) of acetylcholinesterase (AChE). The exact molecular target of MuSK–i...

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Bibliographic Details
Main Authors: Kawakami, Y., Ito, M., Hirayama, M., Sahashi, K., Ohkawara, B., Masuda, A., Nishida, H., Mabuchi, N., Engel, A.G., Ohno, K.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233209/
https://ncbi.nlm.nih.gov/pubmed/22013178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e318237f660
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