Substitutions in the Glycoprotein (GP) of the Candid#1 Vaccine Strain of Junin Virus Increase Dependence on Human Transferrin Receptor 1 for Entry and Destabilize the Metastable Conformation of GP

Candid#1 (Cd1) is an attenuated vaccine strain of Junin virus, the causative agent of Argentine hemorrhagic fever. Although several substitutions are present in Cd1, their importance for attenuation has not been established. We functionally characterized the substitutions present in the Cd1 glycopro...

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Bibliographische Detailangaben
Hauptverfasser: Droniou-Bonzom, Magali E., Reignier, Therese, Oldenburg, Jill E., Cox, Alex U., Exline, Colin M., Rathbun, Jessica Y., Cannon, Paula M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233171/
https://ncbi.nlm.nih.gov/pubmed/21976641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05616-11
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