Phase II Dose Escalation Study of Caspofungin for Invasive Aspergillosis

Our objective was to evaluate the maximum tolerated dose of caspofungin for invasive aspergillosis (IA). The safety and pharmacokinetics of escalating dosages of caspofungin were investigated in IA. Eight patients each received caspofungin 70, 100, 150, or 200 mg once a day (QD). Dose-limiting toxic...

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Main Authors: Cornely, O. A., Vehreschild, J. J., Vehreschild, M. J. G. T., Würthwein, G., Arenz, D., Schwartz, S., Heussel, C. P., Silling, G., Mahne, M., Franklin, J., Harnischmacher, U., Wilkens, A., Farowski, F., Karthaus, M., Lehrnbecher, T., Ullmann, A. J., Hallek, M., Groll, A. H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Clinical Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232774/
https://ncbi.nlm.nih.gov/pubmed/21911573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05134-11
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