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Cell Cycle Heterogeneity in the Small Intestinal Crypt and Maintenance of Genome Integrity

Stem cell quiescence has been hypothesized to suppress the rate at which genetic mutations accumulate within tissues by reducing the number of divisions a cell undergoes. However, recent studies have suggested that stem cells in the small intestine are rapidly dividing. This observation raises the i...

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Autori principali: Pruitt, Steven C., Freeland, Amy, Kudla, Angela
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232743/
https://ncbi.nlm.nih.gov/pubmed/20503265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.450
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