Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism

Neurog3-induced Dll1 expression in pancreatic endocrine progenitors ostensibly activates Hes1 expression via Notch and thereby represses Neurog3 and endocrine differentiation in neighboring cells by lateral inhibition. Here we show in mouse that Dll1 and Hes1 expression deviate during regionalizatio...

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Detalhes bibliográficos
Main Authors: Ahnfelt-Rønne, Jonas, Jørgensen, Mette C., Klinck, Rasmus, Jensen, Jan N., Füchtbauer, Ernst-Martin, Deering, Tye, MacDonald, Raymond J., Wright, Chris V. E., Madsen, Ole D., Serup, Palle
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2012
Assuntos:
Development and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231770/
https://ncbi.nlm.nih.gov/pubmed/22096075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.071761
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