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Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

BACKGROUND: The integration of different 'omics' technologies has already been shown in several in vivo studies to offer a complementary insight into cellular responses to toxic challenges. Being interested in developing in vitro cellular models as alternative to animal-based toxicity assa...

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Autors principals: Jennen, Danyel, Ruiz-Aracama, Ainhoa, Magkoufopoulou, Christina, Peijnenburg, Ad, Lommen, Arjen, van Delft, Joost, Kleinjans, Jos
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231768/
https://ncbi.nlm.nih.gov/pubmed/21880148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-139
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