1,25-Dihydroxyvitamin D(3) inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells

Vitamin D(3) is known to induce regulatory T (Treg) cells by rendering antigen-presenting cells tolerogenic, its direct effect on human naturally occurring Treg cells is unclear. Here, we investigated if and how 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] can directly affect the proliferation and f...

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Autori principali: Khoo, Ai-Leng, Joosten, Irma, Michels, Meta, Woestenenk, Rob, Preijers, Frank, He, Xue-Hui, Netea, Mihai G, van der Ven, André J A M, Koenen, Hans J P M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2011
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230799/
https://ncbi.nlm.nih.gov/pubmed/22044285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2011.03507.x
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