C-Peptide Increases Na,K-ATPase Expression via PKC- and MAP Kinase-Dependent Activation of Transcription Factor ZEB in Human Renal Tubular Cells

BACKGROUND: Replacement of proinsulin C-peptide in type 1 diabetes ameliorates nerve and kidney dysfunction, conditions which are associated with a decrease in Na,K-ATPase activity. We determined the molecular mechanism by which long term exposure to C-peptide stimulates Na,K-ATPase expression and a...

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Auteurs principaux: Galuska, Dana, Pirkmajer, Sergej, Barrès, Romain, Ekberg, Karin, Wahren, John, Chibalin, Alexander V.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230608/
https://ncbi.nlm.nih.gov/pubmed/22162761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028294
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