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Brain-Cocaine Concentrations Determine the Dose Self-Administered by Rats on a Novel Behaviorally Dependent Dosing Schedule

A novel behaviorally dependent dosing (BDD) schedule was used to examine the relationship between doses of cocaine self-administered by rats and brain drug levels within a session. The BDD schedule used a hold-down response to activate a syringe pump. The length of time the lever was held down deter...

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Hlavní autoři: Zimmer, Benjamin A, Dobrin, Carson V, Roberts, David C S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230497/
https://ncbi.nlm.nih.gov/pubmed/21849981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.165
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