Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis

Optic Atrophy 1 (OPA1) is well known as a regulator of mitochondrial dynamics. Now, a new function of OPA1 is uncovered: recruiting protein kinase A to lipid droplets, thereby controlling the activity of perilipin, and hence lipolysis.

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Bibliographische Detailangaben
Hauptverfasser: Greenberg, Andrew S, Kraemer, Fredric B, Soni, Krishnakant G, Jedrychowski, Mark P, Yan, Qing-Wu, Graham, Christine E, Bowman, Thomas A, Mansur, Ayla
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230382/
https://ncbi.nlm.nih.gov/pubmed/22048333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.371
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