Hormonal Therapy Promotes Hormone-Resistant Phenotype by Increasing DNMT Activity and Expression in Prostate Cancer Models

We hypothesized that hormonal therapy favors the development of the hormone-resistant phenotype through epigenetic mechanisms. Human prostate cancer tissues and in vitro and in vivo models were used to verify this hypothesis. We demonstrated that tumor cells continuously treated with bicalutamide (B...

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Detaylı Bibliyografya
Asıl Yazarlar: Gravina, Giovanni Luca, Marampon, Francesco, Piccolella, Margherita, Motta, Marcella, Ventura, Luca, Pomante, Roberto, Popov, Vladimir M., Zani, Bianca M., Pestell, Richard G., Tombolini, Vincenzo, Jannini, Emmanuele A., Festuccia, Claudio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2011
Konular:
Cancer-Oncogenes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230051/
https://ncbi.nlm.nih.gov/pubmed/21990314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1056
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