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Caffeine Acts via A1 Adenosine Receptors to Disrupt Embryonic Cardiac Function

BACKGROUND: Evidence suggests that adenosine acts via cardiac A1 adenosine receptors (A1ARs) to protect embryos against hypoxia. During embryogenesis, A1ARs are the dominant regulator of heart rate, and A1AR activation reduces heart rate. Adenosine action is inhibited by caffeine, which is widely co...

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Autors principals: Buscariollo, Daniela L., Breuer, Gregory A., Wendler, Christopher C., Rivkees, Scott A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229565/
https://ncbi.nlm.nih.gov/pubmed/22164264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028296
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