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Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway

Sustained pressure overload leads to compensatory myocardial hypertrophy and subsequent heart failure, a leading cause of morbidity and mortality. Further unraveling of the cellular processes involved is essential for development of new treatment strategies. We have investigated the hypothesis that...

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Hlavní autoři: Finsen, Alexandra V., Lunde, Ida G., Sjaastad, Ivar, Østli, Even K., Lyngra, Marianne, Jarstadmarken, Hilde O., Hasic, Almira, Nygård, Ståle, Wilcox-Adelman, Sarah A., Goetinck, Paul F., Lyberg, Torstein, Skrbic, Biljana, Florholmen, Geir, Tønnessen, Theis, Louch, William E., Djurovic, Srdjan, Carlson, Cathrine R., Christensen, Geir
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229559/
https://ncbi.nlm.nih.gov/pubmed/22164265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028302
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