Identification of functional regions on the I-Ab molecule by site-directed mutagenesis.

Functional analysis of mutant class II major histocompatibility complex molecules has begun to identify regions important for antibody binding and for T-cell activation. By using in vitro mutagenesis directed at the beta 1 domain of the Ab beta gene we have constructed three structurally distinct mu...

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Main Authors: Cohn, L E, Glimcher, L H, Waldmann, R A, Smith, J A, Ben-Nun, A, Seidman, J G, Choi, E
Formato: Artigo
Idioma:Inglês
Publicado em: 1986
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC322942/
https://ncbi.nlm.nih.gov/pubmed/2418441
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