NADPH Oxidase-2 Derived ROS Dictates Murine DC Cytokine-Mediated Cell Fate Decisions during CD4 T Helper-Cell Commitment

NADPH oxidase-2 (Nox2)/gp91(phox) and p47(phox) deficient mice are prone to hyper-inflammatory responses suggesting a paradoxical role for Nox2-derived reactive oxygen species (ROS) as anti-inflammatory mediators. The molecular basis for this mode of control remains unclear. Here we demonstrate that...

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Detalhes bibliográficos
Main Authors: Jendrysik, Meghan A., Vasilevsky, Sam, Yi, Liang, Wood, Adam, Zhu, Nannan, Zhao, Yongge, Koontz, Sherry M., Jackson, Sharon H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228756/
https://ncbi.nlm.nih.gov/pubmed/22145029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028198
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