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Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).

We evaluated surface areas on proteins that would be accessible to contacts with large (1-nm radius) spherical probes. Such spheres are comparable in size to antibody domains that contain antigen-combining sites. We found that all the reported antigenic sites correspond to segments particularly acce...

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Detalhes bibliográficos
Main Authors: Novotný, J, Handschumacher, M, Haber, E, Bruccoleri, R E, Carlson, W B, Fanning, D W, Smith, J A, Rose, G D
Formato: Artigo
Idioma:Inglês
Publicado em: 1986
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC322830/
https://ncbi.nlm.nih.gov/pubmed/2417241
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