An Emerging Entity: Pancreatic Adenocarcinoma Associated with a Known BRCA Mutation: Clinical Descriptors, Treatment Implications, and Future Directions

BACKGROUND. BRCA1 and BRCA2 germline mutations are associated with an elevated risk for pancreas adenocarcinoma (PAC). Other BRCA-associated cancers have been shown to have greater sensitivity to platinum and poly(ADP-ribose) polymerase (PARP) inhibitors with better clinical outcomes than in sporadi...

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Bibliografiske detaljer
Main Authors: Lowery, Maeve A., Kelsen, David P., Stadler, Zsofia K., Yu, Kenneth H., Janjigian, Yelena Y., Ludwig, Emmy, D'Adamo, David R., Salo-Mullen, Erin, Robson, Mark E., Allen, Peter J., Kurtz, Robert C., O'Reilly, Eileen M.
Format: Artigo
Sprog:Inglês
Udgivet: AlphaMed Press 2011
Fag:
Gastrointestinal Cancer
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228075/
https://ncbi.nlm.nih.gov/pubmed/21934105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0185
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