The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity

Myeloproliferative neoplasms (MPNs) are characterized by overproduction of myeloid lineage cells with frequent acquisition of oncogenic JAK2V617F kinase mutations. The molecular mechanisms that regulate energy requirements in these diseases are poorly understood. Transformed cells tend to rely on fe...

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Autors principals: Reddy, Mamatha M., Fernandes, Margret S., Deshpande, Anagha, Weisberg, Ellen, Inguilizian, Haig V., Abdel-Wahab, Omar, Kung, Andrew L., Levine, Ross L., Griffin, James D., Sattler, Martin
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227767/
https://ncbi.nlm.nih.gov/pubmed/21860432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.225
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