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Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability
The extreme pH and protease-rich environment of the upper gastrointestinal tract is a major obstacle facing orally-administered protein therapeutics, including antibodies. Through protein engineering, several Clostridium difficile toxin A-specific heavy chain antibody variable domains (V(H)Hs) were...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3227653/ https://ncbi.nlm.nih.gov/pubmed/22140551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028218 |
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