Replication and Virus-Induced Transcriptome of HAdV-5 in Normal Host Cells versus Cancer Cells - Differences of Relevance for Adenoviral Oncolysis

Adenoviruses (Ads), especially HAdV-5, have been genetically equipped with tumor-restricted replication potential to enable applications in oncolytic cancer therapy. Such oncolytic adenoviruses have been well tolerated in cancer patients, but their anti-tumor efficacy needs to be enhanced. In this r...

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Detalhes bibliográficos
Main Authors: Dorer, Dominik E., Holtrup, Frank, Fellenberg, Kurt, Kaufmann, Johanna K., Engelhardt, Sarah, Hoheisel, Jörg D., Nettelbeck, Dirk M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227638/
https://ncbi.nlm.nih.gov/pubmed/22140489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027934
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