α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Previous studies have suggested that treatment with antagonists or partial agonists of nicotinic acetylcholine receptors containing the β2 subunit (β2* nAChRs) results in antidepressant-like effects. In the current study we tested 3 novel compounds with different affinity and functional efficacy at...

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Hlavní autoři: Mineur, Yann S., Einstein, Emily B., Seymour, Patricia A., Coe, Jotham W., O’Neill, Brian T., Rollema, Hans, Picciotto, Marina R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227135/
https://ncbi.nlm.nih.gov/pubmed/21566524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FBP.0b013e328347546d
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