MOUSE STRAIN-DEPENDENT CASPASE ACTIVATION DURING ACETAMINOPHEN HEPATOTOXICITY DOES NOT RESULT IN APOPTOSIS OR MODULATION OF INFLAMMATION

The mechanisms of acetaminophen (APAP)-mediated hepatic oncotic necrosis have been extensively characterized. However, it was recently demonstrated that fed CD-1 mice have a transient caspase activation which initiates apoptosis. To evaluate these findings in more detail, outbred (Swiss Webster, SW)...

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Hauptverfasser: Williams, C. David, Koerner, Michael R., Lampe, Jed N., Farhood, Anwar, Jaeschke, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226924/
https://ncbi.nlm.nih.gov/pubmed/22023962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.10.006
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