Autoimmunity to Uroplakin II Causes Cystitis in Mice: A Novel Model of Interstitial Cystitis

BACKGROUND: The pathophysiology of interstitial cystitis (IC) is unknown. Deficits in urothelial cell layers and autoimmune mechanisms may play a role. OBJECTIVE: To examine whether immunization of mice with recombinant mouse uroplakin II (rmUPK2), a bladder-specific protein, would provoke an autoim...

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Main Authors: Altuntas, Cengiz Z., Daneshgari, Firouz, Sakalar, Cagri, Goksoy, Esen, Gulen, M. Fatih, Kavran, Michael, Qin, Jun, Li, Xiaoxia, Tuohy, Vincent K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226908/
https://ncbi.nlm.nih.gov/pubmed/21719190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2011.06.028
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