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Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model
Humans have two nearly identical copies of the Survival Motor Neuron (SMN) gene: SMN1 and SMN2. The two SMN genes code for identical proteins; however, SMN2 predominantly generates a shorter transcript due to skipping of exon 7, the last coding exon. Skipping of SMN2 exon 7 leads to production of a...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225979/ https://ncbi.nlm.nih.gov/pubmed/21654213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.8.4.16224 |
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