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Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones

ABSTRACT: Previous studies showed that cortical pyramidal neurones (PNs) have a dynamic spike threshold that functions as a high-pass filter, enhancing spike timing in response to high-frequency input. While it is commonly assumed that Na(+) channel inactivation is the primary mechanism of threshold...

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Bibliographic Details
Main Authors: Higgs, Matthew H, Spain, William J
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225669/
https://ncbi.nlm.nih.gov/pubmed/21911608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2011.216721
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