Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria

BACKGROUND: Rosetting and cytoadherence of Plasmodium falciparum-infected red blood cells have been associated with severity of malaria. ICAM-1 and CD36 are the main host cell receptors, while PfEMP1-DBLα is a major parasite ligand, which can contribute to rosette formation. This study is aimed at d...

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Autors principals: Horata, Natharinee, Kalambaheti, Thareerat, Craig, Alister, Khusmith, Srisin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224928/
https://ncbi.nlm.nih.gov/pubmed/19650937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-8-184
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