Reversible and regionally selective downregulation of brain cannabinoid CB(1) receptors in chronic daily cannabis smokers

Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies show reversible downregulation of brain cannabinoid CB(1) (cannabinoid receptor type 1) receptors after chronic exposure to cannabis. However, whether downregulation occurs in humans who chronically smoke cannabis...

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Detalhes bibliográficos
Main Authors: Hirvonen, J, Goodwin, RS, Li, C-T, Terry, GE, Zoghbi, SS, Morse, C, Pike, VW, Volkow, ND, Huestis, MA, Innis, RB
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223558/
https://ncbi.nlm.nih.gov/pubmed/21747398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2011.82
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