The C Allele of rs5743836 Polymorphism in the Human TLR9 Promoter Links IL-6 and TLR9 Up-Regulation and Confers Increased B-Cell Proliferation

In humans, allelic variants in Toll-like receptors (TLRs) associate with several pathologies. However, the underlying cellular and molecular mechanisms of this association remain largely unknown. Analysis of the human TLR9 promoter revealed that the C allele of the rs5743836 polymorphism generates s...

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Detalhes bibliográficos
Main Authors: Carvalho, Agostinho, Osório, Nuno S., Saraiva, Margarida, Cunha, Cristina, Almeida, Agostinho J., Teixeira-Coelho, Maria, Ludovico, Paula, Pedrosa, Jorge, Pitzurra, Lucia, Aversa, Franco, Romani, Luigina, Castro, António G., Rodrigues, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223238/
https://ncbi.nlm.nih.gov/pubmed/22132241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028256
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