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Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine
The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 µM NMDA for 3 min and 50 µM DHPG for 5 min, r...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
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Cold Spring Harbor Laboratory Press
2011
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3222894/ https://ncbi.nlm.nih.gov/pubmed/22101180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.024182.111 |
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