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Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine

The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 µM NMDA for 3 min and 50 µM DHPG for 5 min, r...

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Detalhes bibliográficos
Main Authors: Scott-McKean, Jonah J., Costa, Alberto C.S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222894/
https://ncbi.nlm.nih.gov/pubmed/22101180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.024182.111
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