Selenomethionine Incorporation into Amyloid Sequences Regulates Fibrillogenesis and Toxicity

BACKGROUND: The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by seleno...

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Hauptverfasser: Martínez, Javier, Lisa, Silvia, Sánchez, Rosa, Kowalczyk, Wioleta, Zurita, Esther, Teixidó, Meritxell, Giralt, Ernest, Andreu, David, Avila, Jesús, Gasset, María
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222675/
https://ncbi.nlm.nih.gov/pubmed/22132190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027999
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