Insertion Sites in Engrafted Cells Cluster Within a Limited Repertoire of Genomic Areas After Gammaretroviral Vector Gene Therapy

Vector-associated side effects in clinical gene therapy have provided insights into the molecular mechanisms of hematopoietic regulation in vivo. Surprisingly, many retrovirus insertion sites (RIS) present in engrafted cells have been found to cluster nonrandomly in close association with specific g...

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Autors principals: Deichmann, Annette, Brugman, Martijn H, Bartholomae, Cynthia C, Schwarzwaelder, Kerstin, Verstegen, Monique MA, Howe, Steven J, Arens, Anne, Ott, Marion G, Hoelzer, Dieter, Seger, Reinhard, Grez, Manuel, Hacein-Bey-Abina, Salima, Cavazzana-Calvo, Marina, Fischer, Alain, Paruzynski, Anna, Gabriel, Richard, Glimm, Hanno, Abel, Ulrich, Cattoglio, Claudia, Mavilio, Fulvio, Cassani, Barbara, Aiuti, Alessandro, Dunbar, Cynthia E, Baum, Christopher, Gaspar, H Bobby, Thrasher, Adrian J, von Kalle, Christof, Schmidt, Manfred, Wagemaker, Gerard
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222531/
https://ncbi.nlm.nih.gov/pubmed/21862999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.178
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