A Double-modulation Strategy in Cancer Treatment With a Chemotherapeutic Agent and siRNA

5-Fluorouracil (5-FU) is broadly considered the drug of choice for treating human colorectal cancer (CRC). However, 5-FU resistance, mainly caused by the overexpression of antiapoptotic proteins such as Bcl-2, often leads ultimately to treatment failure. We here investigated the effect of Bcl-2 gene...

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Detalhes bibliográficos
Main Authors: Nakamura, Kazuya, Abu Lila, Amr S, Matsunaga, Mariko, Doi, Yusuke, Ishida, Tatsuhiro, Kiwada, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222530/
https://ncbi.nlm.nih.gov/pubmed/21878904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.174
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