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LIGAND-INDEPENDENT PHOSPHORYLATION OF Y869 LINKS MUTANT EGFR SIGNALING TO STAT-MEDIATED GENE EXPRESSION
Activating mutants of EGFR have been identified in a subset of non-small-cell lung cancers. To investigate mutant-driven signaling, we focused on Y869, a residue in the same activation loop where the L858R and L861Q mutations are located. We observed ligand-independent phosphorylation of Y869 in 32D...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3221731/ https://ncbi.nlm.nih.gov/pubmed/17927978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2007.09.002 |
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