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Generalized shrinkage F-like statistics for testing an interaction term in gene expression analysis in the presence of heteroscedasticity

BACKGROUND: Many analyses of gene expression data involve hypothesis tests of an interaction term between two fixed effects, typically tested using a residual variance. In expression studies, the issue of variance heteroscedasticity has received much attention, and previous work has focused on eithe...

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Detalhes bibliográficos
Main Authors: Yang, Jie, Casella, George, McIntyre, Lauren M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221690/
https://ncbi.nlm.nih.gov/pubmed/22044602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-427
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