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Quantifying the impact of chimera MS/MS spectra on peptide identification in large scale proteomics studies

A complicating factor for protein identification within complex mixtures by LC/MS/MS is the problem of “chimera” spectra, where two or more precursor ions with similar mass and retention time are co-sequenced by MS/MS. Chimera spectra show reduced scores due to unidentifiable fragment ions derived f...

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Huvudupphovsmän: Houel, Stephane, Abernathy, Robert, Renganathan, Kutralanathan, Meyer-Arendt, Karen, Ahn, Natalie G., Old, William M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221600/
https://ncbi.nlm.nih.gov/pubmed/20578722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr1003856
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