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Polycystin-1, 2, and STIM1 Interact with IP(3)R to Modulate ER Ca(2+) Release through the PI3K/Akt Pathway
Dysregulation of Ca(2+) signaling and homeostasis has been linked to the development of ADPKD through aberrant functioning of the polycystins. In this study, we investigated the role of the polycystins in modulating Ca(2+) signaling. Expression of full-length PC1 in MDCK cells inhibited intracellula...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
S. Karger AG
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3221273/ https://ncbi.nlm.nih.gov/pubmed/21691089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000330080 |
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