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Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes.

The intervening sequence (IVS) excised from the pre-rRNA of Tetrahymena undergoes a self-catalyzed cleavage-ligation reaction to form a covalently closed circular RNA. This cyclization reaction is kinetically inhibited by ethidium bromide (50% inhibition at 22 +/- 14 microM, greater than 99% inhibit...

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Bibliografske podrobnosti
Main Authors: Tanner, N K, Cech, T R
Format: Artigo
Jezik:Inglês
Izdano: 1985
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC322084/
https://ncbi.nlm.nih.gov/pubmed/2415923
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