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N-PEGylation of a Reverse Turn is Stabilizing in Multiple Sequence Contexts unlike N-GlcNAcylation

The intrinsic stabilization of therapeutic proteins by N-glycosylation can endow them with increased shelf and serum half-lives owing to lower populations of misfolded and unfolded states, which are susceptible to aggregation and proteolysis. Conjugation of polyethylene glycol (PEG) oligomers to nuc...

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Bibliografiska uppgifter
Huvudupphovsmän: Price, Joshua L., Powers, Evan T., Kelly, Jeffery W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220771/
https://ncbi.nlm.nih.gov/pubmed/21939258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200277u
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