The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein

The zinc finger transcription factor Krüppel-like factor 5 (KLF5) is regulated posttranslationally. We identified SMAD ubiquitination regulatory factor 2 (SMURF2), an E3 ubiquitin ligase, as an interacting protein of KLF5 by yeast two-hybrid screen, coimmunoprecipitation, and indirect immunofluoresc...

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Bibliographic Details
Main Authors: Du, James X., Hagos, Engda G., Nandan, Mandayam O., Bialkowska, Agnieszka B., Yu, Bing, Yang, Vincent W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220560/
https://ncbi.nlm.nih.gov/pubmed/21953463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.258707
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