The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein

Stress-induced monoubiquitination of p53 is a crucial event for the nuclear-cytoplasm-mitochondria trafficking and transcription-independent pro-apoptotic functions of p53. Although an intact ubiquitination pathway and a functional nuclear export sequence are required for p53 nuclear export, the rol...

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Main Authors: Muscolini, Michela, Montagni, Elisa, Palermo, Vanessa, Di Agostino, Silvia, Gu, Wei, Abdelmoula-Souissi, Salma, Mazzoni, Cristina, Blandino, Giovanni, Tuosto, Loretta
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220532/
https://ncbi.nlm.nih.gov/pubmed/21953469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.279539
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