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Tunable degradation of maleimide-thiol adducts in reducing environments
Addition chemistries are widely used in preparing biological conjugates, and in particular, maleimide-thiol adducts have been widely employed. Here we show that the resulting succinimide thioether formed by a Michael type addition of a thiol to N-ethylmaleimide (NEM), generally accepted as stable, c...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220410/ https://ncbi.nlm.nih.gov/pubmed/21863904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200148v |
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