Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival

A major problem of ageing is progressive impairment of neuronal function and ultimately cell death. Since sex steroids are neuroprotective, their decrease with age may underlie age-related neuronal degeneration. To test this, we examined Purkinje cell numbers, plasma sex steroids and cerebellar neur...

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Detalhes bibliográficos
Main Authors: Janmaat, Sonja, Akwa, Yvette, Doulazmi, Mohamed, Bakouche, Joëlle, Gautheron, Vanessa, Liere, Philippe, Eychenne, Bernard, Pianos, Antoine, Luiten, Paul, Groothuis, Ton, Baulieu, Etienne-Emile, Mariani, Jean, Sherrard, Rachel M., Frédéric, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220403/
https://ncbi.nlm.nih.gov/pubmed/21222044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-010-9203-3
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